what is Field-Cycling NMR?
Field-cycling NMR (Nuclear Magnetic Resonance) is a technique that involves changing the magnetic field strength during an NMR experiment. In traditional NMR, a constant magnetic field is applied to the sample, causing the nuclei in the sample to resonate at a specific frequency. By detecting the resonance frequency, we can learn about the sample's chemical and physical properties. In field-cycling NMR, the magnetic field is periodically varied over a range of strengths, causing the sample's resonant frequency to change as well. This allows for the observation of additional information about the sample, including its relaxation properties and interactions with the surrounding environment.
How to perfom Field-Cycling NMR?
Performing magnetic field-dependent measurements in high-resolution NMR spectra requires specialized instruments. To conduct field-cycling studies on high-field NMR spectrometers, we have developed several related instruments, including the High-Field Field-Cycler. This instrument can be integrated with commercial high-field NMR spectrometers to enable wide range field-cycling studies. To learn more about our related technologies and products, please visit our Technologies and Products.
What kinds of applications use such techniques?
Field-cycling NMR (FCNMR) has a variety of applications in fields such as material science, structural biology, and medical imaging. In material science, it can be used to study polymer dynamics, while in structural biology, it can provide insights into membrane and protein dynamics. FCNMR can also be used to measure NMR relaxivity for contrast agents in magnetic resonance imaging (MRI) applications. Many studies in the literature have used FCNMR for these applications. To learn more about specific applications and recent developments in FCNMR, please visit Applications and Field-Cycling Communications.