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What is Field-Cycling NMR?

time profile of field cycling

Field-cycling NMR goes beyond conventional NMR by dynamically varying the magnetic field during the experiment. While standard NMR operates at a fixed field, field-cycling accesses a continuous range of field strengths within a single experiment — revealing relaxation dispersion profiles, molecular dynamics, and field-dependent interactions that are simply invisible at a fixed field. FCNMR's shuttle-based approach preserves full high-field resolution throughout, making it uniquely compatible with existing spectrometer investments.

Special instruments required for Field-Cycling NMR

Our High-Field Field-Cycler (HFFC) is a rapid sample shuttler that integrates directly with commercial high-field NMR spectrometers. It transports the NMR sample swiftly between stray-field positions and the acquisition center, enabling relaxation dispersion measurements across a wide field range, while fully preserving the resolution and sensitivity of your high-field system.

High field relaxometry sample shuttling mechanism animation

What is illuminated NMR?

Illuminated NMR combines light excitation with NMR spectroscopy to probe photochemical and photobiological processes in real time. Photo-CIDNP (Chemically Induced Dynamic Nuclear Polarization) is a key technique: light-activated photosensitizers transfer spin polarization to target nuclei, dramatically enhancing NMR signal sensitivity. This opens a direct window onto radical reaction mechanisms, molecular dynamics, and photoinduced structural changes — at concentrations as low as the nano-molar range.

time profile of illumination during the NMR experiment

Special instruments required for illuminated NMR

In-situ illuminated NMR: Animation of the compact photo-CIDNP module for fixed-field NMR spectrometers.

We offer two illuminator models for commercial high-field NMR spectrometers, each addressing a different experimental geometry.

The In-Situ NMR Illuminator couples a light source directly to the sample via a light guide inserted into the NMR tube. Compact and spectrometer-agnostic, it enables photo-CIDNP and other illumination experiments at the acquisition field without any hardware modification.

Field-cycling photo-CIDNP: Animation of the illumination system for variable-field NMR studies.

The second model, the Field-Cycling NMR Illuminator, delivers non-contact optical excitation directly to the sample at variable stray-field positions inside the spectrometer. Its fiber-free design eliminates mechanical interference during shuttling, allowing the sample to move rapidly and precisely between the illumination spot and the acquisition position. This shuttle-illumination module is an exclusive add-on to the High-Field Field-Cycler (HFFC).

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